Molecules in Systemic Autoimmune Diseases Autoantibodies to T Cell Costimulatory
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منابع مشابه
Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice.
Autoimmune lupus nephritis is dependent on infiltrating autoreactive leukocytes and Igs. B7 costimulatory molecules (B7-1 and B7-2) provide signals essential for T cell activation and Ig class switching. In MRL-Faslpr mice, a model of human lupus, although multiple tissues are targeted for autoimmune injury, nephritis is fatal. We identified intrarenal B7-1 and B7-2 expression, restricted to ki...
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تاریخ انتشار 1999